Phone:
(409) 747-6803
NMR Lab:
(409) 747-6822
Fax:
(409) 747-6850
Route: 1157
Mailing Address:
301 University Blvd.
Galveston, Texas
77555-1157
Location:
Room 2.110
Dockside Bldg.
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Dr. David E. Volk
My research interests are generally related to human health and involve the study of cell signalling proteins, DNA repair enzymes, infectious diseases, and unusual DNA mis-matches or adducts. More specifically:
1) Cancer related: MutY DNA Repair Enzyme, benzo[a]pyrene:DNA adducts and A:G mismatches
2) Biodefense: West Nile, Dengue Fever (pictured above left), Yellow Fever and Omsk Hemorrhagic Fever
3) Immune Response: Thioaptamers for immunological regulation mediated by NF-kappaB proteins
4) Cell Signalling: SH3 domains and Glucocorticoid Receptors
5) Quantum Mechanics Studies:Theoretical Studies of DNA basepairs and DNA binding to metals and proteins
I have been with the Department of Biochemistry and Molecular Biology (formerly called HBCG) at the University of Texas Medical Branch at Galveston since 1996. The NMR facility is located in the Dockside Building (building 73 on the campus map) and contains Varian Unity+ 600 and 750 MHz magnets. A new Varian Inova 800 MHz magnet was installed in the spring of 2005. Thank you for your interest in my research at UTMB.
Sincerely,
David E. Volk, Ph.D.
devolk@utmb.edu
Dr. David Volk's Publications
(30) Base-pairing Properties of the Oxidized Cytosine Derivative, 5-Hydroxy Uracil.
V. Thiviyanathan, A. Somasunderam, D. E. Volk, T.K. Hazra, S. Mitra and D. G. Gorenstein
Biochem. Biophys. Res. Commun. 366:752-757, 2008.
(29) Ab initio base-pairing energies of an oxidized thymine product, 5-formyluracil,
with standard DNA bases at the BSSE-free DFT and MP2 theory levels.
D. E. Volk, V. Thiviyanathan, A. Somasunderam and D. G. Gorenstein,
Org. Biomol. Chem. 2007, 5(10), 1554-1558.
(28) NMR Assignments of the Yellow Fever Virus Envelope Protein Domain III
D. E. Volk, S. A. Gandham, F. J. May, A. Anderson, A. D. T. Barrett and D. G. Gorenstein.
Biomolecular NMR Assignments 2007, 1(1):49-50, 2007.
(27) Structure of the Envelope Protein Domain III of Dengue-4 Virus
D. E. Volk, Y.-C. Lee, X. Li, V. Thiviyanathan, G. D. Gromowski, L. Li, A. Lamb, D. W. Beasley, A. D. T. Barrett and D. G. Gorenstein,
Virology 2007, 364(1), 147-154.
(26) NMR Assignment of the Dengue 4 Virus Envelope Protein Domain III
D. E. Volk, Y.-C. Lee, X. Li, A. D. T. Barrett and D. G. Gorenstein,
Journal of Biomolecular NMR 2006, 36(suppl. 5):62.
(25) Ab Initio Base-pairing Energies of Uracil and 5-Hydroxy-Uracil with Standard DNA Bases at the BSSE-free DFT and MP2 Theory Levels
D. E. Volk, V. Thiviyanathan, A. Somasunderam and D. G. Gorenstein
Organic and Biomolecular Chemistry 2006, 4(9), 1741-1745.
(24) Structure of the Envelope Protein Domain III of Omsk Hemorrhagic Fever Virus.
D. E. Volk, L. Chavez, D. W. C. Beasley, A. D. T. Barrett, M. R. Holbrook and D. G. Gorenstein
Virology 2006, 351(1), 188-195.
(23) NMR structure of the viral peptide linked to the genome (VPg) of poliovirus.
C. Schein, N. Oezguen, D. E. Volk, R. Garimella, A. Paul and W. Braun
Peptides 2006, 27(7), 1676-1684.
(22) Novel, structure-based mechanism for uridylylation of the genome-linked peptide (VPg) of picornaviruses.
C. Schein, D. E. Volk, N. Oezguen, A. Paul and W. Braun
PROTEINS:Structure, Function, and Bioinformatics 2006, 63:719-726.
(21) Selection of Thioaptamers for Diagnostics and Therapeutics
X. Yang, H. Wang, D.W.C. Beasley, D. E. Volk, X. Zhao, B. A. Luxon,
L. O. Lomas, N. Herzog, J. F. Aronson, A.D.T. Barrett, J. F. Leary and D. G. Gorenstein
Annal. N. Y. Acad. Sci. 2006, 1082:116-119.
(20) 5-Hydroxy Uracil Can Form Stable Base Pairs With all
Four Bases in a DNA Duplex.
V. Thiviyanathan, A. Somasunderam, D.E. Volk, and D.G. Gorenstein
Chemical Communications. 2005(3) 400-402.
(19) TATA-Box Binding Protein Induces Structure in the
Recombinant Glucocorticoid Receptor AF1 Domain.
R. Kumar, D.E. Volk, J. Li, J.C. Lee, D.G. Gorenstein and E.B. Thompson
Proc. Nat. Acad. Sci. U.S.A. 2004, 101, 16425-16430.
(18) Solution structure and antibody binding studies of the envelope protein domain III from the New York strain of West Nile virus.
D.E. Volk, D. W. C. Beasley, D. A. Kallick, M.R. Holbrook, A.D.T. Barrett and D. G. Gorenstein
J. Biolog. Chem. 2004, 279,38755-38761.
(17) 1H, 13C, and 15N resonance assignments
for domain III of the West Nile Virus envelope protein.
D.E. Volk, D. A. Kallick, M.R. Holbrook, D.W.C. Beasley, A.D.T. Barrett and D.G. Gorenstein
J. Biomol. NMR 2004, 29, 445-446.
(16) NMR Structure of the Apo-S100P protein.
Y.-C. Lee, D.E. Volk, V. Thiviyanathan, Q. Kleerekoper, A.X. Gribenko, S. Zhang
D.G. Gorenstein, G. I. Makhatadze and B. A. Luxon.
J. Biomol. NMR 2004, 29, 399-402.
(15) Solution Structure of a Cis-Opened (10R)-N6-
Deoxyadenosine Adduct of
(9S,10R)-9,10-Epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene
in a DNA Duplex
D.E. Volk, V. Thiviyanathan, J.S. Rice, B.A. Luxon, J.H. Shah, H. Yagi, J.M. Sayer, D.M. Jerina, and D.G. Gorenstein
Biochemistry 2003, 42, 1410-1420.
(14)
Initiation of Repair of A:G Mismatches is
Modulated by Sequence Context
A.M. Sanchez, D.E. Volk, D.G. Gorenstein, and R.S. Lloyd
DNA Repair 2003, 2(8), 863-878.
(13) Solution Structure, Dynamics and Thermodynamics of the
Native
State Ensemble of the Sem-5 C-terminal SH3 Domain
J.C. Ferreon, D.E. Volk, B.A. Luxon, D.G. Gorenstein and V.J. Hilser,
Biochemistry 2003, 42, 5582-5591.
(12) Solution structure and design of dithiophosphate backbone
aptamers targeting transcription factor NF-kappa B
D.E. Volk, X. Yang, S.M. Fennewald, D.J. King, S. Bassett,
S. Venkitachalam, N. Herzog, B.A. Luxon, and D.G. Gorenstein,
Bioorganic Chemistry 2002, 30, 396-419.
(11) An ab initio study of phosphorothioate and phosphorodithioate interactions with sodium cation.
D.E. Volk, T.D. Power, D.G. Gorenstein and B.A. Luxon,
Tetrahedron Letters 2002, 43, 4443-4447.
(10) Potential Double-Flipping Mechanism by E. coli MutY.
P.G. House, D.E. Volk, V. Thiviyanathan, R.C. Manual, B.A. Luxon, D.G. Gorenstein, and R.S. Lloyd,
Progress in Nucleic Acid Research and Molecular Biology, 2001, 68, 349-364.
(9) NMR Evidence for Syn-Anti Interconversion of a Trans Opened (10R)-dA
Adduct of Benzo[a]pyrene (7S,8R)-Diol (9R,10S)-Epoxide in a DNA Duplex.
D.E. Volk, J.S. Rice, B.A. Luxon, H.J.C. Yeh, C. Liang, G. Xie, J.M. Sayer, D.M. Jerina, and D.G. Gorenstein,
Biochemistry 2000, 39, 14040-14053.
(8)
Structural Similarities between MutT and the C-Terminal Domain of MutY.
D.E. Volk, P.G. House,V. Thiviyanathan, B.A. Luxon, S. Zhang, R.S. Lloyd and D.G. Gorenstein,
Biochemistry (Accelerated Publication) 2000, 39, 7331-7336.
(7) 1H, 13C, and 15N resonance assignments of the C-terminal
domain of MutY: An Adenine glycosylase active on G:A mismatches.
D.E. Volk, V. Thiviyanathan, P.G. House, R.S. Lloyd and D.G. Gorenstein,
J. Biomol. NMR: 1999, 14, 385-386
(6) SnCl4
S. Castellino and D.E. Volk,
"Encyclopedia of Reagents for Organic Synthesis".
Leo Paquette, Editor-in-Chief, Wiley: 1995
(5) Allyltributylstannane
S. Castellino and D.E. Volk,
"Encyclopedia of Reagents for Organic Synthesis".
Leo Paquette, Editor-in-Chief, Wiley: 1995
(4) Crotylstannane
S. Castellino and D.E. Volk,
"Encyclopedia of Reagents for Organic Synthesis".
Leo Paquette, Editor-in-Chief, Wiley: 1995
(3) SnCl4/ZnCl2
S. Castellino and D.E. Volk,
"Encyclopedia of Reagents for Organic Synthesis".
Leo Paquette, Editor-in-Chief, Wiley: 1995
(2) Chelation Controlled Reactions of Et2AlCl and Carbomethoxy
Substituted Dioxolanes.
S. Castellino and D.E. Volk,
Tetrahedron Letters: 1993, 34, 967
(1) Substituent Effects on the Gas Phase Acidity of Silane.
M.S. Gordon, D.E. Volk, and D.R. Gano,
J. Am. Chem. Soc.: 1989, 111, 9273
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