Phone:
(409) 747-6809
NMR Lab:
(409) 747-6822
Fax:
(409) 747-6850
Route: 1157
Mailing Address:
301 University Blvd.
Galveston, Texas
77555-1157
Location:
Room 2.118
Dockside Bldg.
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Dr. Varatharasa Thiviyanathan
I have been with the Department of Human Biological Chemistry and Genetics (HBCG) at the University of Texas Medical Branch at Galveston since 1994. My research interests include NMR spectroscopy of proteins and nucleic acids. In particular, I am investigating the solution structure of a number of nucleic acids from Hepatitis C, Rhinovirus, Adenovirus, and others. Below you'll find a list of my publications (click the titles to read the manuscripts or click the images for larger pictures) and to the left you'll find additional UTMB web sites that may be of interest to you. The NMR facility is located in the Dockside Building (building 73 on the campus map) and contains Varian Unity+ 600 and 750 MHZ magnets. A new Varian Inova 800 MHz magnet will be installed in the fall of 2004. Thank you for your interest in my research at UTMB.
Varatharasa (Thivi) Thiviyanathan, Ph.D.
thivi@nmr.utmb.edu
Dr. Thiviyanathan's Publications
Base-pairing Properties of the Oxidized Cytosine Derivative, 5-Hydroxy Uracil.
V. Thiviyanathan, A. Somasunderam, D. E. Volk, T.K. Hazra, S. Mitra and D. G. Gorenstein
Biochem. Biophys. Res. Commun. 366:752-757, 2008.
Combinatorial selection and delivery of thioaptamers.
V. Thiviyanathan, A. D. Somasunderam and D. G. Gorenstein
Biochem. Soc. Trans. 2007, 35:50-52.
Ab initio base-pairing energies of an oxidized thymine product, 5-formyluracil,
with standard DNA bases at the BSSE-free DFT and MP2 theory levels.
D. E. Volk, V. Thiviyanathan, A. Somasunderam and D. G. Gorenstein,
Org. Biomol. Chem. 2007, 5(10), 1554-1558.
Structure of the Envelope Protein Domain III of Dengue-4 Virus
D. E. Volk, Y.-C. Lee, X. Li, V. Thiviyanathan, G. D. Gromowski, L. Li, A. Lamb, D. W. Beasley, A. D. T. Barrett and D. G. Gorenstein,
Virology 2007, 364(1), 147-154.
Delivery of double-stranded DNA thioaptamers into HIV-1 infected cells for antiviral activity
M. R. Ferguson, D. R. Rojo, A. Somasunderam, V. Thiviyanathan, B. Ridley, X. Yang and D.G. Gorenstein
Biochem. Biophys. Res. Commun. 2006, 344(3), 792-797.
Ab Initio Base-pairing Energies of Uracil and 5-Hydroxy-Uracil with Standard DNA Bases at the BSSE-free DFT and MP2
Theory Levels
D. E. Volk, V. Thiviyanathan, A. Somasunderam and D. G. Gorenstein
Organic and Biomolecular Chemistry 2006, 4(9), 1741-1745.
Combinatorial Selection, Inhibition and Antiviral Activity of DNA
Thioaptamers Targeting the RNase H Domain of HIV-1 Reverse Transcriptase.
A. Somasunderam, M. R. Ferguson, D. R. Rojo, V. Thiviyanathan, X. Li, W. A. O'Brien and D.G. Gorenstein
Biochemistry 2005 , 44(30), 10388-10395.
5-Hydroxy Uracil Can Form Stable Base Pairs With all
Four Bases in a DNA Duplex.
V. Thiviyanathan, A. Somasunderam, D.E. Volk, and D.G. Gorenstein
Chemical Communications. 2005(3), 400-402.
High-resolution structure of a picornaviral internal cis-acting RNA replication element (cre).
V. Thiviyanathan, Y. Yang, K. Kaluarachchi, R. Rijnbrand, D.G. Gorenstein and S. M. Lemon
Proc. Nat. Acad. Sci. U.S.A. 2004, 101(34), 12688-12693.
Mutational and Structural Analysis of Stem-Loop IIIc of the Hepatitis C Virus and GB Virus B Internal Ribosome Entry Sites.
R. Rijnbrand, V. Thiviyanathan, K. Kaluarachchi, S. M. Lemon and D.G. Gorenstein
J. Mol. Biol. 2004, 343, 805-817.
NMR Structure of the Apo-S100P protein.
Y.-C. Lee, D.E. Volk, V. Thiviyanathan, Q. Kleerekoper, A.X. Gribenko, S. Zhang
D.G. Gorenstein, G. I. Makhatadze and B. A. Luxon.
J. Biomol. NMR 2004, 29, 399-402.
Solution Structure of a Cis-Opened (10R)-N6-
Deoxyadenosine Adduct of (9S,10R)-9,10-Epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene
in a DNA Duplex
D.E. Volk, V. Thiviyanathan, J.S. Rice, B.A. Luxon, J.H. Shah, H. Yagi,
J.M. Sayer, D.M. Jerina, and D.G. Gorenstein
Biochemistry 2003, 42, 1410-1420.
Solution Structure of a DNA Duplex Containing 8-Hydroxy- 2'-Deoxyguanosine
Opposite Deoxyguanosine
V. Thiviyanathan, A. Somasunderam, T.K. Hazra, S. Mitra and D.G. Gorenstein,
Journal of Molecular Biology 2003, 325, 443-442.
Structure of Hybrid Backbone Methylphosphonate DNA Heteroduplexes:
Effect of R and S Stereochemistry
V. Thiviyanathan, K.V. Vyazovkina, E.K. Gozansky, E Bichenchova,
T.V. Abramova, B.A. Luxon, A.V. Lebedev and D.G. Gorenstein,
Biochemistry 2002, 41, 827-838.
Potential Double-Flipping Mechanism by E. coli MutY.
P.G. House, D.E. Volk, V. Thiviyanathan, R.C. Manual, B.A. Luxon, D.G. Gorenstein, and R.S. Lloyd,
Progress in Nucleic Acid Research and Molecular Biology, 2001, 68, 349-364.
Structural Similarities between MutT and the C-Terminal Domain of MutY.
D.E. Volk, P.G. House,V. Thiviyanathan, B.A. Luxon, S. Zhang, R.S. Lloyd and D.G. Gorenstein,
Biochemistry (Accelerated Publication) 2000, 39, 7331-7336.
Solution Conformation of a Bulged Adenosine Base
in an RNA Duplex by Relaxation Matrix Refinement
V. Thiviyanathan, A.B. Guliaev, N.B. Leontis and D.G. Gorenstein,
Journal of Molecular Biology : 2000, 300, 1143-1156
Hybrid-hybrid matrix structural refinement of a DNA
Three-way junction from 3D NOESY-NOESY.
V. Thiviyanathan, B.A. Luxon, N.B. Leontis, N. Illangasekare, D.G. Donne and D.G. Gorenstein,
Journal of Biomol. NMR : 1999, 14, 209-221
E. Gozanski, V. Thiviyanathan, B.A. Luxon and D.G. Gorenstein,
"Hybrid-Hybrid Matrix Method for 3D NOESY-NOESY Data Refinements", in
Modern Techniques in Protein NMR ,
N. Rama Krishna and L.J. Berliner, Eds., Plenum Press, Vol. 17, 163-199 (1999)
1H, 13C, and 15N resonance
assignments of the C-terminal
domain of MutY: An Adenine glycosylase active on G:A mismatches.
D.E. Volk, V. Thiviyanathan, P.G. House, R.S. Lloyd and D.G. Gorenstein,
J. Biomol. NMR: 1999, 14, 385-386
V. Thiviyanathan, N. Illangasekara, E. Gozanski, F. Zhu, N.B. Leontis, B.A. Luxon and D.G. Gorenstein,
"P-31 NOESY-NOESY Hybrid-Hybrid Matrix Refinement of a DNA Three-Way Junction",
American Chemical Society Symposium on Computational Biology, Series 682, in
Molecular Modeling of Nucleic Acids
(N.B. Leontis and J. SantaLucia, Jr., Eds., Chapter 10, pp 167-180 (1998)
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